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Fumikazu Okajima Selected Research

G-Protein-Coupled Receptors (Receptors, G Protein Coupled)

1/2021Metal-Stimulated Interleukin-6 Production Through a Proton-Sensing Receptor, Ovarian Cancer G Protein-Coupled Receptor 1, in Human Bronchial Smooth Muscle Cells: A Response Inhibited by Dexamethasone.
11/2020A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism.
10/2020The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.
4/2020Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells.
4/2020Species-Dependent Enhancement of Ovarian Cancer G Protein-Coupled Receptor 1 Activation by Ogerin.
10/2019Characterization of molecular mechanisms of extracellular acidification-induced intracellular Ca2+ increase in LβT2 cells.
1/2019Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone.
4/2018Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species.
10/2017The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction.
8/2017Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4.
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Fumikazu Okajima Research Topics

Disease

23Ovarian Neoplasms (Ovarian Cancer)
01/2021 - 10/2004
8Inflammation (Inflammations)
10/2017 - 03/2008
7Atherosclerosis
09/2010 - 05/2002
5Neoplasms (Cancer)
04/2020 - 02/2004
5Asthma (Bronchial Asthma)
01/2014 - 03/2008
5Glioma (Gliomas)
12/2009 - 03/2003
4Pancreatic Neoplasms (Pancreatic Cancer)
06/2012 - 01/2002
3Respiratory Hypersensitivity
01/2013 - 03/2008
3Ascites
06/2012 - 02/2004
2Acidosis
10/2017 - 07/2008
2Myocardial Infarction
10/2017 - 05/2016
2Insulin Resistance
01/2015 - 09/2012
2Neoplasm Metastasis (Metastasis)
11/2012 - 06/2012
2Rheumatoid Arthritis
11/2008 - 10/2008
2Cardiovascular Diseases (Cardiovascular Disease)
10/2006 - 05/2002
1Occupational Asthma
01/2021
1Atopic Dermatitis (Atopic Eczema)
01/2021
1Hypertrophy
01/2021
1Cerebral Infarction
10/2020
1Ischemia
10/2020
1Brain Injuries (Brain Injury)
10/2020
1Pituitary Neoplasms (Pituitary Adenoma)
04/2020
1Hyperpituitarism
04/2020
1Amelogenesis Imperfecta
10/2016
1Acute Lung Injury
12/2015
1Lung Injury
12/2015
1Fibrosis (Cirrhosis)
12/2015
1Pulmonary Fibrosis (Fibrosing Alveolitis)
12/2015
1Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2015
1Hypertension (High Blood Pressure)
01/2015
1Cerebrovascular Disorders (Cerebrovascular Occlusion)
01/2015
1Alzheimer Disease (Alzheimer's Disease)
03/2014
1Multiple Sclerosis
03/2014
1Neurodegenerative Diseases (Neurodegenerative Disease)
03/2014
1Cough
01/2014
1Respiratory Tract Diseases (Respiratory Tract Disease)
01/2014
1Breast Neoplasms (Breast Cancer)
11/2013
1Eosinophilia
01/2013
1Metaplasia
01/2013
1Pain (Aches)
11/2012
1Osteoporosis
11/2012
1Glucose Intolerance
09/2012

Drug/Important Bio-Agent (IBA)

26G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2021 - 10/2004
21Protons (Proton)IBA
01/2021 - 10/2004
9lysophosphatidic acidIBA
11/2013 - 02/2004
7CytokinesIBA
01/2021 - 02/2004
6Proteins (Proteins, Gene)FDA Link
01/2021 - 02/2008
5LipidsIBA
11/2013 - 02/2004
5sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
02/2008 - 10/2002
4Type C PhospholipasesIBA
11/2020 - 03/2003
4Small Interfering RNA (siRNA)IBA
11/2012 - 02/2004
4Lysophosphatidic Acid ReceptorsIBA
06/2012 - 02/2004
3Connective Tissue Growth FactorIBA
01/2019 - 10/2011
3Messenger RNA (mRNA)IBA
12/2015 - 03/2003
3Glucose (Dextrose)FDA LinkGeneric
01/2014 - 06/2011
3HDL LipoproteinsIBA
11/2008 - 07/2003
3Inositol PhosphatesIBA
10/2005 - 10/2004
2Interleukin-6 (Interleukin 6)IBA
01/2021 - 01/2019
2CobaltIBA
01/2021 - 08/2017
2Dexamethasone (Maxidex)FDA LinkGeneric
01/2021 - 01/2021
2Lactic Acid (Lactate)FDA LinkGeneric
04/2020 - 10/2017
2LipopolysaccharidesIBA
12/2015 - 04/2011
2ChemokinesIBA
12/2015 - 10/2010
2Lipoproteins (Lipoprotein)IBA
03/2014 - 11/2008
2ProstaglandinsIBA
11/2013 - 09/2010
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
11/2013 - 10/2008
2Immunoglobulin E (IgE)IBA
01/2013 - 03/2008
2OvalbuminIBA
01/2013 - 03/2008
25S,12R,18R- trihydroxy- 6Z,8E,10E,14Z,16E- eicosapentaenoic acidIBA
09/2010 - 03/2008
2TensinsIBA
12/2009 - 02/2008
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
12/2009 - 02/2008
23- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acidIBA
03/2009 - 02/2004
2Pertussis ToxinIBA
03/2009 - 03/2003
2Biomarkers (Surrogate Marker)IBA
11/2008 - 04/2007
2oxidized low density lipoproteinIBA
11/2004 - 05/2002
1Dinitrochlorobenzene (DNCB)IBA
01/2021
1NickelIBA
01/2021
1salvianolic acid AIBA
01/2021
1MetalsIBA
01/2021
1Minocycline (Cyclops)FDA LinkGeneric
10/2020
1ProlactinIBA
04/2020
1Growth Hormone (Somatotropin)IBA
04/2020
1Hormones (Hormone)IBA
04/2020
1ogerinIBA
04/2020
1ManganeseIBA
08/2017
1Pharmaceutical PreparationsIBA
05/2016
1CollagenIBA
12/2015
1Bleomycin (Blenoxane)FDA LinkGeneric
12/2015
1Collagen Type I (Type I Collagen)IBA
12/2015
1Triglycerides (Triacylglycerol)IBA
01/2015
1HDL CholesterolIBA
01/2015
1Acid Sensing Ion ChannelsIBA
01/2014
1lysophosphatidylethanolamineIBA
11/2013
1GTP-Binding Proteins (G-Protein)IBA
01/2013
1Dinoprostone (PGE2)FDA Link
11/2012
1Glucagon (Glukagon)FDA Link
09/2012
13- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonylamino)- 3- methyl- 5- isoxazolyl)benzylsulfanyl)propanoic acid methyl esterIBA
06/2012
1Matrix Metalloproteinases (MMPs)IBA
06/2012

Therapy/Procedure

2Intraperitoneal Injections
01/2021 - 12/2015
1Oral Administration
06/2012